Portal for the Eye Care Professionals
Call Our Toll Free: (858) 605-9055

Studies on the singlet oxygen scavenging mechanism of human macular pigment

Studies on the singlet oxygen scavenging mechanism of human macular pigment.

By: Binxing Li, Faisal Ahmed, Paul S. Bernstein

It is thought that direct quenching of singlet oxygen and scavenging free radicals by macular pigment carotenoids is a major mechanism for their beneficial effects against light-induced oxidative stress. Corresponding data fromhumantissue remains unavailable, however. In the studies reported here, electron paramagnetic resonance (EPR) spectroscopy was used to measure light-induced singlet oxygen generation in post-mortem human macula and retinal pigment epithelium/choroid (RPE/choroid). Under white-light illumination, production of singlet oxygen was detected in RPE/choroid but not in macular tissue, and we show that exogenously added macular carotenoids can quench RPE/choroid singlet oxygen. When the singlet oxygen quenching ability of the macular carotenoids was investigated in solution, it was shown that a mixture of meso-zeaxanthin, zeaxanthin, and lutein in a ratio of 1:1:1 can quench more singlet oxygen than the individual carotenoids at the same total concentration.

Download (PDF, Unknown)

Comments are closed.

Address

GUARDION HEALTH SCIENCES
15150 Avenue of Science
Suite 200
SAN DIEGO, CA 92128

Phone: 858.605.9055
Fax: 858.630.5543

EMAIL US

Disclaimer

Reference in this site to any specific commercial product, process, or service, or the use of any trade, firm or corporation name is for the information and convenience of the public, and does not constitute endorsement, recommendation, or favoring by Guardion Health Sciences.